Key result
Thrombolysis may improve the prognosis of pulmonary embolism associated with circulatory collapse, but has no place in treating small emboli without cardiovascular compromise due to hemorrhage risk.
Why the study?
Does thrombolysis improve prognosis in patients with pulmonary embolism?
Systematic Review
Does thrombolysis improve prognosis in patients with pulmonary embolism?
Thrombolysis is beneficial for PE patients with circulatory collapse but contraindicated in those with small emboli and no cardiovascular compromise due to bleeding risks.
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Reinforces withholding thrombolysis in stable PE; leaves open benefit in submassive cases without RCTs.
Harris et al. (2005) conducted a systematic review in Pulmonary embolism. Thrombolysis was evaluated. Thrombolysis may improve the prognosis of pulmonary embolism associated with circulatory collapse, but has no place in treating small emboli without cardiovascular compromise due to hemorrhage risk.
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