Key result
Intravenous administration of 100 mg hydrocortisone caused marked elevation of plasma cortisol in volunteers, and suprarenal failure was very uncommon among 30 very sick patients.
Population
30 very sick patients and an unspecified number of volunteers
Authors
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Suprarenal failure appears uncommon in critically ill patients; leaves open optimal hydrocortisone dosing and requires prospective validation.
Suprarenal failure is uncommon in very sick patients, and small doses of intravenous hydrocortisone markedly elevate plasma cortisol levels.
Sainsbury et al. (1981) studied Suprarenal failure (n=30). Hydrocortisone was evaluated on Plasma cortisol levels and evidence of suprarenal failure. Intravenous administration of 100 mg hydrocortisone caused marked elevation of plasma cortisol in volunteers, and suprarenal failure was very uncommon among 30 very sick patients.
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