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July 31, 2026Restorative Dentistry & EndodonticsOpen Access

Microbial leakage and marginal adaptation of alkasite restorative material in Class II cavities: an in vitro study

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Authors

KCKah Hup ChewNYNorhayati YusopKMKasmawati Mokhtar

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Overview

In vitro study reveals microbial leakage differences in various restorative materials, indicating clinical implications.

Key Points

  • The study aims to investigate how different restorative materials impact microbial leakage and marginal adaptation in proximal cavities.
  • Conducted on 66 human third molars with standardized Class II cavities.
  • Used a dual-chamber model with Streptococcus mutans to assess microbial leakage over 40 days.
  • Employed qualitative analysis through scanning electron microscopy and various statistical methods including Kaplan-Meier analysis.
  • Significant differences in microbial leakage were observed among restorative materials, with a notable difference between Cention N and Filtek Z350XT (p = 0.037).
  • Cention N showed a longer average time before microbial leakage occurred compared to other materials.
  • Qualitative SEM analysis supported findings on the interfacial properties of the restorations.

Cite This Study

Chew et al. (2026) studied this question.

synapsesocial.com/papers/6a6c46c0747664a1aa73bb77https://doi.org/10.5395/rde.2026.51.e31
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