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Case report describes Graves’ orbitopathy in anophthalmic patients, indicating unique insights into disease mechanisms.
BACKGROUND: Graves' orbitopathy (GO) affects approximately 0.1% of the population. GO in anophthalmic patients is extremely rare and may provide insights into the pathogenesis of this disease. METHODS: We describe four cases of GO in patients with previously acquired anophthalmia in one eye. RESULTS: In all cases, the anophthalmic eye showed both clinical and radiological evidence of GO. In two patients, optic nerve compression was present. In all cases, involvement of extraocular muscles was radiologically symmetrical when comparing the two orbits. CONCLUSIONS: GO in anophthalmic patients is a rare combination of ocular morbidities. Early recognition and appropriate management of GO in such patients are important if visual function is to be preserved. Whether anophthalmia predisposes to GO in susceptible patients is unclear. This rare group of patients may provide unique opportunities for studying the pathogenetic mechanisms in GO.
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Pérez‐López et al. (2026) studied this question.
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