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Longitudinal study finds increased monocyte activation in early treated children with perinatal HIV, suggesting risk for later health issues.
Early ART initiation in children with perinatal HIV (CHIV) greatly improves long-term outcomes. However, little is known of the long-term inflammatory profile. Our longitudinal study compared 26 inflammatory markers in early treated CHIV and HIV-unexposed children. CHIV displayed extensive immune marker elevations, clustered around monocyte activation. Despite early-antiretroviral therapy and sustained viral suppression, these children are at increased risk of non-communicable diseases.
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Davies et al. (2026) studied this question.
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