Key result
Antibiotic-eluting envelopes reduced major cardiac implantable electronic device infections by 40% (HR 0.60) compared to standard of care in high-risk patients.
Why the study?
Despite optimal antimicrobials and preventive strategies, cardiac implantable electronic device infections are increasing over time, driving significant morbidity, mortality, and healthcare costs.
Do antibiotic-eluting envelopes prevent infections and provide cost-effectiveness in patients receiving cardiac implantable electronic devices?
Do antibiotic-eluting envelopes prevent infections and provide cost-effectiveness in patients receiving cardiac implantable electronic devices?
This review summarizes the rationale, efficacy, and cost-effectiveness of antibiotic-eluting envelopes for preventing CIED infections.
May support AEE use in high-risk CIED patients; leaves open optimal risk stratification and cost-effectiveness.
Infections related to cardiac implantable electronic devices (CIED) are associated with significant morbidity and mortality. Despite optimal use of antimicrobials and other preventive strategies, the incidence of CIED infections is increasing over time leading to considerable costs to the healthcare systems. Recently, antibiotic-eluting envelopes (AEEs) have been introduced as a promising technology to prevent CIED infections. This review will address the current evidence on stratification of CIED infection risk, present the rationale behind AEE, and summarize the currently available evidence for CIED infection prevention as well as demonstrate the cost-effectiveness of this novel technology.
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Traykov et al. (2022) conducted a review in Cardiac Implantable Electronic Device (CIED) Infections. Antibiotic-eluting envelopes vs. Standard of care was evaluated on Major CIED infection (HR 0.60, 95% CI 0.36-0.98, p=0.04). Antibiotic-eluting envelopes reduced major cardiac implantable electronic device infections by 40% (HR 0.60) compared to standard of care in high-risk patients.
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