Key result
Antibacterial TYRX™ envelope use can reduce the incidence of CIED infection by more than 80% in high-risk patients based on non-randomised cohort studies.
Why the study?
What are the strategies for preventing and managing CIED infections in high-risk patients?
What are the strategies for preventing and managing CIED infections in high-risk patients?
Antibacterial envelopes and advanced lead extraction techniques are important strategies for managing the increasing incidence of CIED infections.
Answers are grounded in this paper and cite their sources.
Antibacterial envelopes may reduce CIED infections >80% in high-risk patients; leaves open confirmation from ongoing RCTs before routine use.
The incidence of infection following implantation of cardiac implantable electronic devices (CIEDs) is increasing at a faster rate than that of device implantation. Patients with a CIED infection usually require hospitalisation and complete device and lead removal. A significant proportion die from their infection. Transvenous lead extraction (TLE) is associated with rare but serious complications including major vascular injury or cardiac perforation. Operator experience and advances in lead extraction methods, including laser technology and rotational sheaths, have resulted in procedures having a low risk of complication and mortality. Strategies for preventing CIED infections include intravenous antibiotics and aseptic surgical techniques. An additional method to reduce CIED infection may be the use of antibacterial TYRX™ envelope. Data from non-randomised cohort studies have indicated that antibacterial envelope use can reduce the incidence of CIED infection by more than 80 % in high-risk patients and a randomised clinical trial is ongoing.
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Tarakji et al. (2016) conducted a review in Cardiac implantable electronic device (CIED) infection. Antibacterial TYRX™ envelope was evaluated on Incidence of CIED infection (>80% reduction). Antibacterial TYRX™ envelope use can reduce the incidence of CIED infection by more than 80% in high-risk patients based on non-randomised cohort studies.
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