Population
colVIII knock-out mice and wild type mice subjected to aortic banding to induce pressure overload; neonatal…
Comparison
Collagen VIII knock-out (col8KO) vs Wild type (WT) mice
Design
Preclinical
Follow-up
Up to 56 days
Key result
Collagen VIII knock-out in mice subjected to pressure overload promoted early mortality at 3-9 days and left ventricular dilatation while reducing myofibroblast differentiation and fibrosis.
Authors
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Findings in mice caution against fibrosis reduction without preserving adaptive remodeling; leaves open collagen VIII as a target in pressure-overload states.
Lack of collagen VIII in mice reduces fibrosis but promotes early mortality and left ventricular dilatation in response to pressure overload, highlighting its role in adaptive remodeling.
Skrbic et al. (2015) studied Pressure overload-induced remodelling. Collagen VIII knock-out (col8KO) vs. Wild type (WT) mice was evaluated on Mortality and left ventricular dilatation. Collagen VIII knock-out in mice subjected to pressure overload promoted early mortality at 3-9 days and left ventricular dilatation while reducing myofibroblast differentiation and fibrosis.