In conclusion, it has been shown that cryosurgery equals the anatomic results of excisional surgery, and exceeds excisional surgery in patient acceptance and patient comfort. Of the media available, LN2 is the most destructive; N2O provides adequate therapy if the time to reach tissue destruction is remembered before starting the freezing; CO2 has too small a temperature range to be dependable as an universal agent for use in proctology.
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John O’Connor (1975) studied this question.