Key result
Salvianolic acid B plus paeonol dose-dependently improves hemorrheology and lipid profiles in ischemic rabbits.
The purpose of this study was to determine the therapeutic effect of salvianolic acid b and paeonol on coronary disease. The ischemia myocardial animal model is induced by administering pituitrin (20 μg·kg(-1)) intravenously via the abdominal vein. A combination of salvianolic acid b and paeonol (CSAP) (5, 10 and 15 mg/kg BW) was administrated to experimental rabbits. Biochemical indices were evaluated during six weeks of intervention. We found that the compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can markedly and dose-dependently reduce fibrinogen and malonaldehyde levels, increase the HDL level, improve blood viscosity and plasma viscosity in rabbits. In addition, the medicine can still reduce the ratio of NO/ET and the contents of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) in a dose-dependent manner. This study demonstrates that compound of salvianolic acid b and paeonol (5, 10 and 15 mg/kg BW) can improve the blood hemorrheology, decrease oxidative injury and repair the function of blood vessel endothelium, and subsequently prevent the development of Coronary disease.
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Yang et al. (2010) studied Myocardial ischemia. Combination of salvianolic acid b and paeonol was evaluated on Blood lipid metabolism and hemorrheology indices. A combination of salvianolic acid b and paeonol (5-15 mg/kg) dose-dependently reduced fibrinogen, increased HDL, and improved blood and plasma viscosity in myocardial ischemia rabbits.
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