Suzuki Reaction within the Core−Corona Nanoreactor of Poly(N-isopropylacrylamide)-Grafted Pd Nanoparticle in Water

A nanoreactor of poly( N -isopropylacrylamide)-grafted Pd nanoparticle (Pd@PNIPAM) is proposed for the Suzuki reaction performed in the sole solvent of water. The Pd@PNIPAM nanoparticle has a core of Pd nanoparticle and a corona of poly( N -isopropylacrylamide) brushes. The Pd@PNIPAM nanoparticle can act as a nanoreactor for the Suzuki reaction since the grafted poly( N -isopropylacrylamide) brushes provide a nanoenvironment for guest molecules. Both hydrophilic and hydrophobic reactants can be enriched in the nanoreactor of Pd@PNIPAM, and therefore the Suzuki reaction within the nanoreactor is performed in water at room temperature or above the phase-transition temperature of the corona-forming brushes of poly( N -isopropylacrylamide). Besides, the nanoreactor of Pd@PNIPAM can be recycled due to the reversible phase-transition of the poly( N -isopropylacrylamide) brushes.