Key result
Extracellular protons inhibit hERG maximal conductance by blocking the external channel pore, evidenced by voltage-dependent channel inhibition (δ = 0.18).
Population
hERG cardiac K+ channels (including wild-type and mutants like S620T and histidine substitutions)
Comparison
Acidic pH (extracellular protons) vs Normal pH / varying external K+ or Na+…
Design
Preclinical
Authors
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May heighten ischemic arrhythmia risk via hERG inhibition; leaves open distinct mechanisms for conductance loss and deactivation.
This study demonstrates that acidosis-induced inhibition of hERG channels, which can predispose to arrhythmias during ischemia, is mediated by proton block of the external channel pore.
Slyke et al. (2012) studied Acidosis. Extracellular protons (low pH) vs. Normal pH was evaluated on hERG channel maximal conductance. Extracellular protons inhibit hERG maximal conductance by blocking the external channel pore, evidenced by voltage-dependent channel inhibition (δ = 0.18).
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