Aim: The detection rate of gastrointestinal subepithelial tumors (SETs) has been arising. This study aimed to investigate the clinicopathological features of SETs in different gastrointestinal locations. Methods: From January 2015 to December 2021, the retrospective medical records of 1965 patients with 1998 SETs diagnosed by endoscopy and histopathology were collected from multiple endoscopic centers in Shanghai. The clinicopathological features and distribution characteristics of SETs were analyzed. Results: The current study consisted of 1965 patients (57.2 ± 12.0 years), and 1998 SETs were identified. The mean diameter of SETs was 11.2±8.0mm. Gastrointestinal stromal tumor (GIST; n=750, 37.5%) was the most common type of SETs, followed by leiomyoma (n=641, 32.1%), lipoma (n=199, 9.9%), neuroendocrine tumor (n=158,7.9%), ectopic pancreas (n=152, 7.6%), cyst (n=30, 1.5%), schwannoma (n=13, 0.7%), inflammatory fibroid polyp (n=12, 0.6%), glomus tumor (n=9, 0.5%), Bruner’s gland adenoma (n=8, 0.4%), granular cell tumor (n=6, 0.3%) and other rare type (n=20, 1.0%). Of all the SETs, 1257 SETs (62.9%) were identified in the stomach, GIST was the most frequent SETs in the stomach; 412 SETs (20.6%) in the esophagus, the majority (n=377) were leiomyomas; 55 SETs (2.8%) in the duodenum, the most common was ectopic pancreas (n=15); 274 SETs (13.7%) in the colorectum, the most common was neuroendocrine tumors, which accounted for 147 cases. Conclusions: The distribution and histopathologic characteristics of SETs in different segments of gastrointestinal tract were significantly different. Hence, the diagnosis and management of SETs can be improved by identifying their distribution characteristics.
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Zhao et al. (2024) studied this question.
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