The known metabolites, indole-3-aldehyde, indole-3-carboxylic acid, cyclo-Leu-Val, cyclo-Pro-Leu and phenyl acetamide were isolated from Streptoverticillium olivoreticuli together with pimprinin derivatives. Four more complex natural products having strong vesicatory toxicity, olivoretin A, B, C and D, were also isolated and based on the chemical correlation with D, A was proved to be O-methyl olivoretin D. By X-ray analysis the structure of olivoretin D, having strong epigenetic activities, was found to have exactly the same structure as teleocidin B.
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Sakai et al. (1984) studied this question.
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