Key result
Veratridine stimulates Na+ and Ca2+ influx in cultured embryonic cardiac cells, increasing the initial rate of Na+ influx by a factor of 5 at 0.1 mM without affecting efflux rates.
Veratridine stimulates Na+ and Ca2+ influx in cultured embryonic cardiac cells without affecting efflux rates.
Effects in embryonic cell culture warrant clinical caution; leaves open mechanistic questions on adult cardiac ion fluxes.
Veratridinestimulates Na+ and Ca"+ influx in the embryonic cardiac cell in culture; it does not influence Na+, Rb+ (a substitute for K+), or Ca'+ efflux rates.Veratridine increases the initial rate of Na+ influx by a factor of 5 at 0.1 mM.Its half-maximum (KO.S,reratridine)) effect is observed at 22 PM.
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Fosset et al. (1977) studied this question. Veratridine stimulates Na+ and Ca2+ influx in cultured embryonic cardiac cells, increasing the initial rate of Na+ influx by a factor of 5 at 0.1 mM without affecting efflux rates.
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