Key result
This exploratory review highlights the roles of postmenopausal estrogen decline, the HPA axis, and inflammaging in Takotsubo syndrome, proposing a new therapeutic approach based on autonomic imbalance.
Why the study?
Because age and gender appear to play major roles in Takotsubo syndrome, the authors aimed to examine age- and gender-specific aspects, chronic stress responses, inflammaging, and propose a new potential therapeutic approach.
This review highlights the interplay between psychosocial stress, inflammaging, and autonomic imbalance in Takotsubo syndrome, proposing a novel therapeutic perspective.
Takotsubo syndrome (TTS) is a cardiomyopathy that presents clinically as a transient and reversible left ventricular wall motion abnormality (LVWMA) that can recover spontaneously within hours to weeks. Studies have shown that it mainly affects older people. Postmenopausal women in particular have an increased prevalence. Physical and emotional stress are widely discussed and generally recognized trigger factors. As age also appears to play a major role in the development of TTS, this review will take a closer look at age- and gender-specific aspects. First and foremost, postmenopausal women and the associated lower oestrogen concentration should be mentioned here. Another important role is played by the hypothalamic-pituitary-adrenal (HPA) axis and the associated glucocorticoid-dependent negative feedback and the resulting immune response. Inflammaging is another term that is increasingly used in connection with TTS. In the following, these risk factors are considered in more detail and linked to the increased sympathetic activity as a possible consequence of chronic stress. Based on the imbalance between the sympathetic and parasympathetic nervous system, we venture an explorative proposal and would like to present a new possible therapeutic approach.
No takes yet. Share an insight, caveat, or question.
Frank et al. (2023) conducted a review in Takotsubo syndrome. Psychosocial stress response and inflammaging was evaluated. This exploratory review highlights the roles of postmenopausal estrogen decline, the HPA axis, and inflammaging in Takotsubo syndrome, proposing a new therapeutic approach based on autonomic imbalance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: