Mitochondria are considered the major cellular site for hydrogen peroxide production, a process that is kinetically controlled by the availability of oxygen and nitric oxide to cytochrome oxidase and of ADP to F1-ATPase. The multisite regulation of mitochondrial respiration and energy-transducing pathways support a critical regulatory role of mitochondrion in cell signaling pathways. The cellular steady-state levels of hydrogen peroxide and the role of mitochondria in maintaining these levels are reviewed.
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Boveris et al. (2000) studied this question.