What question did this study set out to answer?

To examine the cerebrovascular and systemic vascular complications associated with mucin-producing malignancies.

April 1, 1989Neurology

Cerebrovascular complications of mucinous cancers

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Authors

LALonnie L. AmicoMercy Hospital and Medical Center LCLouis R. CaplanUniversity of Arkansas at Little Rock CTChinnamma ThomasLoyola University Chicago

Discussion

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Implication

Autopsy series demonstrates extensive thrombosis and cerebral infarction in mucinous cancer patients, indicating a cancer-associated coagulopathy drives occlusive vascular disease.

Key Points

To examine the cerebrovascular and systemic vascular complications associated with mucin-producing malignancies.
Postmortem autopsy and microscopic evaluation of systemic, extracranial, and intracranial vessels and brain tissue in 6 patients with mucinous cancer (colonic origin, n=2; pancreatic origin, n=2; pulmonary origin, n=2).
Necropsy revealed extensive thrombosis across large and small systemic, extracranial, and intracranial arteries and veins, accompanied by multiple cerebral infarcts and petechial hemorrhages.
Histopathologic analysis identified mucin within occluded blood vessels, macrophages, and necrotic cerebral tissue, which corresponded to clinical presentations of strokes and encephalopathy.

Cite This Study

Amico et al. (1989) studied this question.

synapsesocial.com/papers/6a6cbedde5469ee92bdf9e3f https://doi.org/10.1212/wnl.39.4.522

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Implication

Autopsy series demonstrates extensive thrombosis and cerebral infarction in mucinous cancer patients, indicating a cancer-associated coagulopathy drives occlusive vascular disease.

Cerebrovascular complications of mucinous cancers

Discussion

Member takes

Implication

Key Points

Cite This Study

Cerebrovascular complications of mucinous cancers

Discussion

Member takes

Implication

Key Points

Cite This Study

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