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A prompt, significant increase in urinary excretions of magnesium and calcium and a decrease in urinary excretion of potassium follows ingestion of ethanol and galactose. The oxidative metabolism of alcohol and galactose are rate-limited by the availability of the DPN-flavoprotein-cytochrome enzymes for hydrogen transport. If the cation transport mechanisms were dependent upon this same respiratory system, a competitive inhibition of magnesium and calcium reabsorption and potassium secretion in the distal tubule might well explain our findings.
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Lindeman et al. (1964) studied this question.
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