Key result
Mebudipine and dibudipine (1-10 μM) are at least as potent as amlodipine in inhibiting PE-induced perfusion pressure and improving kidney perfusion in isolated kidneys of diabetic rats.
Why the study?
Do mebudipine and dibudipine improve vascular flow in isolated kidneys of diabetic rats compared to amlodipine?
Do mebudipine and dibudipine improve vascular flow in isolated kidneys of diabetic rats compared to amlodipine?
The novel calcium channel blockers mebudipine and dibudipine improve kidney perfusion in diabetic rats with similar potency to amlodipine.
Mebudipine and dibudipine may preserve renal function in hypertension; leaves open comparative efficacy and safety versus established agents.
Calcium channel blockers are clinically useful vasodilators, used widely in the treatment of hypertension. These agents are reported to preserve or improve renal function in patients with essential hypertensive renal disease or diabetic renal disease. Among the classes of calcium channel blockers, dihydropyridine derivatives are widely used because of their potent vasodilating activity and weak cardiodepressant action. Mebudipine and dibudipine are two new 1,4-dihydropyridine calcium channel blockers that recently have been synthesized. In previous research mebudipine and dibudipine showed considerable relaxant effects on vascular and ileal smooth muscle cells. In this study we investigated the effects of these new drugs on vascular flow of isolated kidney of diabetic rat and compare their potencies to amlodipine. It is concluded that mebudipine and dibudipine (1-10 μM) are at least as potent as amlodipine in inhibiting PE-induced perfusion pressure in isolated kidney of diabetic rats. These new dihydropyridines improve kidney perfusion of diabetic rat in the setting of PE infusion. Similarly, amlodipine.
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Sepehr-Ara et al. (2010) studied Diabetic rat (isolated kidney). Mebudipine and dibudipine vs. Amlodipine was evaluated on PE-induced perfusion pressure in isolated kidney. Mebudipine and dibudipine (1-10 μM) are at least as potent as amlodipine in inhibiting PE-induced perfusion pressure and improving kidney perfusion in isolated kidneys of diabetic rats.
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