Key result
An updated computational methodology efficiently identified drug-induced changes and quantitated IC50 values in line with published values for five drugs using human stem cell-derived cardiomyocytes.
Why the study?
Human induced pluripotent stem cell-derived cardiomyocytes have drug screening potential, but their usefulness is limited by electrophysiological immaturity compared with native adult human cardiomyocytes.
Population
Stem cell-derived cardiac microtissues tested with five drugs with known effects
Design
Preclinical computational and experimental study
Authors
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Enhances iPSC-cardiomyocyte drug screening fidelity; extends prior computational methods but leaves open clinical validation.
An updated computational methodology improves the prediction of drug effects on mature human cardiomyocytes using data from immature stem cell-derived cardiomyocytes.
Jæger et al. (2019) studied Drug response in cardiomyocytes. Updated computational methodology with action potential model vs. Previous computational procedures was evaluated on Quantitation of IC50 and identification of drug-induced changes. An updated computational methodology efficiently identified drug-induced changes and quantitated IC50 values in line with published values for five drugs using human stem cell-derived cardiomyocytes.
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