Key result
A microtechnique in plastic plates for complement-fixation tests provided comparable results to the standard macrotechnique in tubes for delineating antigenic relationships of foot-and-mouth disease virus subtypes.
The microtechnique for complement-fixation tests is a reliable and economical alternative to the standard tube method for analyzing subtype strains of foot-and-mouth disease virus.
May economize FMD complement-fixation testing; leaves open standardization in wider diagnostic use.
A comparison was made between a macrotechnique in tubes and a microtechnique in plastic plates for complement-fixation tests, using strains of three subtypes of the Asia 1 type of foot-and-mouth disease (FMD) virus. The results obtained with these techniques were found to be comparable and delineated the antigenic relationships of the three strains employed. The microtechnique was considered to be both economical with reagents and capable of similar accuracy and reproducibility to that of the standard method in tubes. It was concluded that the antigenic analysis of subtype strains of FMD virus can be conveniently carried out by the use of the microtechnique as described.
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Darbyshire et al. (1972) studied Foot-and-mouth disease virus. Microtechnique in plastic plates vs. Macrotechnique in tubes was evaluated on Antigenic relationship (R values) between FMD virus strains. A microtechnique in plastic plates for complement-fixation tests provided comparable results to the standard macrotechnique in tubes for delineating antigenic relationships of foot-and-mouth disease virus subtypes.
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