Selective Iodine‐Catalyzed Intermolecular Oxidative Amination of C(sp³)H Bonds with ortho‐Carbonyl‐Substituted Anilines to Give Quinazolines

Access to quinazolines: The selective amination of C(sp3)H bonds adjacent to nitrogen or oxygen atoms of N-alkylamides, ethers, or alcohols with ortho-carbonyl-substituted anilines constitutes the first step in a tandem annulation that leads to quinazolines in good to excellent yields (see scheme; NIS=N-Iodosuccinimide, TBHP=tert-butyl hydroperoxide). The selectivity of the amination of primary and secondary CH bonds is also noteworthy (left: >3:1, right: >99:1).