One of the first protein kinases to be discovered was the enzyme that is activated in response to cAMP, cAMP-dependent protein kinase (Walsh et al. 1968). In the intervening decades, many diverse kinases have been identified (Hanks et al. 1988). They include kinases that transfer phosphate to serine and threonine as well as those transferring phosphate to tyrosine. Some kinases are activated in response to second messengers, such as cAMP, Ca++, and diacylglycerol, whereas others are activated by primary signals such as growth factors. The protein kinase family includes transforming proteins coded by oncogenes as well as growth factor receptors (for reviews, see Boyer and Krebs 1986).
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Taylor et al. (1988) studied this question.