Neuroendocrinology and Impotence

Editorials1 January 1983Neuroendocrinology and ImpotenceRICHARD F. SPARK, M.D.RICHARD F. SPARK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptImpotence—erectile dysfunction is the preferred term—is a poorly understood, common medical problem that may result from psychogenic, vascular, neurologic, or hormonal disorders. Several new studies have encouraged a more hopeful outlook for patients with impotence. Providing the basis of this optimism are recent developments that allow a better understanding of the role of a hypothalamic hormone that controls pituitary gonadal function.The testicle possesses two functional units. The seminiferous tubules are responsible for spermatogenesis and fertility, and the Leydig cell is responsible for the production of testosterone and potency. One pituitary gonadotropin, follicle stimulating hormone, stimulates spermatogenesis; luteinizing hormone stimulates...References1. BELCHETZPLANTNAKAIKEOGHKNOBIL PTYEE. Hypophyseal response to continuous and intermittent delivery of hypothalamic-gonadotropin-releasing hormone. Science. 1978;202:631-3. CrossrefMedlineGoogle Scholar2. CROWLEYCOMITEVALERIVIERLORIAUXCUTLER WFWJDG. Therapeutic use of pituitary desensitization with a long-acting LHRH agonist: a potential new treatment for idiopathic precocious puberty. J Clin Endocrinol Metab. 1981;52:370-2. CrossrefMedlineGoogle Scholar3. YOSHIMOTOMORIDERAIMURA YKH. Restoration of normal pituitary gonadotropin reserve by administration of luteinizing-hormone-releasing hormone in patients with hypogonadotropic hypogonadism. N Engl J Med. 1975;292:242-5. CrossrefMedlineGoogle Scholar4. CROWLEYMCARTHUR WJ. Induction of puberty in hypogonadotropic males: use of low-dose pulsatile luteinizing hormone releasing hormone (LHRH) administration. In: Proceedings of the 62nd Annual Meeting of The Endocrine Society. Bethesda, Maryland: Endocrine Society; 1980. (Abstract 743). Google Scholar5. CROWLEYBEITINSVALE WIW. The biologic activity of a potent analogue of gonadotropin-releasing hormone in normal and hypogonadotropic men. N Engl J Med. 1980;302:1052-7. CrossrefMedlineGoogle Scholar6. LINDEDOELLEALEXANDER RTN. Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotropin-releasing hormone agonist in normal men. N Engl J Med. 1981;305:663-7. CrossrefMedlineGoogle Scholar7. REEVESSEQUINLEFEBVREMASSICOTTEGIGUERE JCFJV. Similar binding characteristics of the LHRH receptor using 1251-(D-Ser (TBU)6) LHRH-EA in rat pituitary, ovary, and testis. In: Proceedings of the 62nd Annual Meeting of The Endocrine Society. Bethesda, Maryland: Endocrine Society; 1980. (Abstract 383). Google Scholar8. CHENZORNHALBERGWIELAND JEMR. Antibodies to testosterone-3 bovine serum albumin applied to assay of serum 17-betaol-androgens. Clin Chem. 1971;17:581-4. CrossrefMedlineGoogle Scholar9. RUBENSDHONTVERMUELEN RMA. Further studies on Leydig cell function in old age. J Clin Endocrinol Metab. 1974;39:40-5. CrossrefMedlineGoogle Scholar10. SPARROWBOSSEROWE DRJ. The influence of age, alcohol consumption, and body build on gonadal function in men. J Clin Endocrinol Metab. 1980;51:508-13. CrossrefMedlineGoogle Scholar11. CHOPRATULCHINSKY ID. Status of estrogen-androgen balance in hyperthyroid men with Graves' disease. J Clin Endocrinol Metab. 1974;38:269-77. CrossrefMedlineGoogle Scholar12. SPARKWHITECONNOLLY RRP. Impotence is not always psychogenic: newer insights into hypothalamic-pituitary-gonadal dysfunction. JAMA. 1980;243:750-5. CrossrefMedlineGoogle Scholar13. GRIFFINWILSON JJ. The syndromes of androgen resistance. N Engl J Med. 1980;302:198-209. CrossrefMedlineGoogle Scholar14. CARTERTYSONTOLISVANVLIETFAIMANFRIESEN JJGSCH. Prolactin-secreting tumours and hypogonadism in 22 men. N Engl J Med. 1978;299:847-52. CrossrefMedlineGoogle Scholar15. BURROWWORTZMANREWCASTLEHOLGATEKOVACS GGNRK. Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med. 1981;304:156-8. CrossrefMedlineGoogle Scholar16. Prolactinomas: bromocriptine rules O. K.? [Editorial]. Lancet. 1982;1:430-1. MedlineGoogle Scholar17. PRESCOTTKENDALL-TAYLORHALL RPK. Hyperprolactinaemia in men: response to bromocriptine therapy. Lancet. 1982;1:245-9. CrossrefMedlineGoogle Scholar18. MAGRINIEBINERBURCKARDTSELBER GJPJ. Study on the relationship between plasma prolactin levels and androgen metabolism in men. J Clin Endocrinol Metab. 1976;43:944-7. CrossrefMedlineGoogle Scholar19. BAUMVREEBURG MJ. Copulation in castrated male rats following combined treatment with estradiol and dihydrotestosterone. Science. 1973;182:283-5. CrossrefMedlineGoogle Scholar20. SPARKO'REILLYWILLSRANSILBERGLAND RGCBR. Hyperprolactinaemia in males with and without pituitary macroadenomas. Lancet. 1982;2:129-31. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD F. SPARK, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byORIGINAL RESEARCH—PATHOPHYSIOLOGY: Clinical Biologic Pathophysiologies of Women's Sexual DysfunctionInsuficiência androgênica de origem hipotálamo-hipofisária em dois homens com disfunção sexualPossible hypothalamic impotencemale counterpart to hypothalamic amenorrhea?Hyperprolactinemia and Impotence: Why, when and how to InvestigatePituitary-Testicular Reserve in Men with Low Serum Testosterone and Normal Serum Luteinizing HormoneOral and Transcutaneous Pharmacologic Agents in the Treatment of ImpotenceHormone kinetics after intramuscular testosterone cypionateTreatment of impotenceAssessment of the Immediate and Long-term Effects of Pharmacologically Induced Penile Erections in the Treatment of Psychogenic and Organic ImpotenceSexual Dysfunction in the Male Dialysis Patient: Pathogenesis, Evaluation, and TherapyMale Hypogonadism—Current Concepts and TrendsComparison of leuprolide and diethylstilbestrol for stage D2 adenocarcinoma of prostateAutonomic Nervous System and EpilepsyDiagnostic Approaches to Sexuality in the Medically IllEndocrine Dysfunction in Impotence: Incidence, Significance and Cost-Effective ScreeningHYPOGONADISM, HYPERPROLACTINAEMIA, AND TEMPORAL LOBE EPILEPSY IN HYPOSEXUAL MEN 1 January 1983Volume 98, Issue 1Page: 103-105KeywordsErectile dysfunctionFollicle stimulating hormoneGonadotropinsLuteinizing hormoneNeuroendocrinologyProlactinTestosterone ePublished: 1 December 2008 Issue Published: 1 January 1983 PDF downloadLoading ...