Key result
In mice, quantifying bleeding volume from body weight changes correlated well with hemoglobin levels (r2=0.990, P<0.0001) and was more sensitive than bleeding time in detecting partial platelet inhibition (P<0.01).
Population
Mice treated with prasugrel at various doses or mice deficient of FcRγ
Comparison
Prasugrel or genetic disruption of FcRγ vs Untreated or wild-type mice
Design
Preclinical
Authors
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Optimizes mouse tail bleeding assay sensitivity; leaves open translation to human antithrombotic testing.
p-value: p=<0.01
Measuring bleeding volume and pattern, in addition to bleeding time, improves the sensitivity and accuracy of the mouse tail bleeding assay.
Yang Liu (2012) studied Bleeding assay optimization. Prasugrel / FcRγ deficiency was evaluated on Bleeding volume and bleeding time (p=<0.01). In mice, quantifying bleeding volume from body weight changes correlated well with hemoglobin levels (r2=0.990, P<0.0001) and was more sensitive than bleeding time in detecting partial platelet inhibition (P<0.01).
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