Key result
Hibernating myocardium was detected in 78% of patients after MI treated with thrombolysis, and its presence did not influence mortality or postinfarction chest pain (53.1% vs 25%).
Why the study?
Does the presence of hibernating myocardium influence clinical outcomes in patients after acute myocardial infarction treated with thrombolysis?
Cohort (n=41)
Does the presence of hibernating myocardium influence clinical outcomes in patients after acute myocardial infarction treated with thrombolysis?
Absolute Event Rate: 53.1% vs 25%
Hibernating myocardium is common early after thrombolysis for MI but does not appear to significantly impact short-term mortality or post-infarction chest pain.
Hibernating myocardium may be common early after thrombolyzed MI; leaves open its link to outcomes and need for viability-guided therapy.
OBJECTIVE: To establish the incidence of hibernating myocardium after myocardial infarction treated with thrombolysis and to observe differences in the clinical outcome between patients with and without hibernating tissue. METHODS: 41 patients underwent gated positron emission tomography with 18-fluorodeoxyglucose and 13N-ammonia at a median of eight days after first myocardial infarction. RESULTS: All 41 subjects had a matched perfusion-metabolism deficit in the region of myocardium indicated as the site of infarction by an electrocardiograph; 32 patients (78%) had scans which also showed at least one area of reduced blood flow and contraction with a concomitant increase in glucose uptake, representing hibernating myocardium. Patients were followed up at a median of six months: all 41 were alive and none had sustained a further infarct or cardiac arrhythmia; 17 subjects with hibernating tissue (53.1%) and two without (25%) reported chest pain after myocardial infarction. CONCLUSIONS: Hibernating myocardium is relatively common shortly after myocardial infarction treated with thrombolysis. It does not influence mortality or the incidence of postinfarction chest pain.
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Adams et al. (1996) conducted a cohort in Acute myocardial infarction treated with thrombolysis (n=41). Hibernating myocardium vs. Absence of hibernating myocardium was evaluated on Postinfarction chest pain. Hibernating myocardium was detected in 78% of patients after MI treated with thrombolysis, and its presence did not influence mortality or postinfarction chest pain (53.1% vs 25%).
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