Key result
Acute psychological stress and postural change produced a significant decrease in plasma volume (p < .001) that correlated with increases in mean arterial pressure (r = .65, p < .0001).
Why the study?
Do acute psychological stress and postural change decrease plasma volume in healthy individuals?
Do acute psychological stress and postural change decrease plasma volume in healthy individuals?
p-value: p=<.001
Acute psychological stress and postural change cause rapid, transient decreases in plasma volume, likely due to blood pressure-driven fluid shifts into interstitial spaces.
Stress may transiently lower plasma volume in healthy adults via BP shifts; leaves open relevance to patients or outcomes.
In this study, we examined the effects of psychological stress on calculated plasma volume, the relationship of these changes to changes in hematologic and hemodynamic factors, and the time course of plasma volume changes. Plasma volume changes were assessed using mass densitometry techniques, which measured changes in blood and plasma density. Hematologic and hemodynamic variables were assessed in 40 healthy men and women during a mental arithmetic (math) or benign reading task and during postural change (standing). Results indicated that math and posture change produced a significant decrease in plasma volume (ps < .001) and increases in blood pressure (ps < .001), blood and plasma density (ps < .001), and total plasma protein (p < .001). Correlations were observed between plasma volume changes and changes in systolic (r = .55, p < .0001), diastolic (r = .61, p < .0001), and mean (r = .65, p < .0001) arterial pressure during math; plasma volume and blood pressure returned to baseline within 12 min following the math task. These results suggest that an important mechanism for stress-induced decreases in plasma volume is increased blood pressure leading to increased fluid shifts from the vasculature into the interstitial spaces.
No takes yet. Share an insight, caveat, or question.
Patterson et al. (1995) studied Healthy (n=40). Mental arithmetic and postural change vs. Benign reading task and baseline was evaluated on Plasma volume changes (p=<.001). Acute psychological stress and postural change produced a significant decrease in plasma volume (p < .001) that correlated with increases in mean arterial pressure (r = .65, p < .0001).