Key result
Exposure to 100% oxygen at 3 ATA resulted in significantly different survival times (range 9.8-21.7 hours) and toxic responses among 18 inbred mouse strains.
Why the study?
Does the response to hyperbaric oxygen vary among different inbred strains of mice?
Does the response to hyperbaric oxygen vary among different inbred strains of mice?
Effect estimate: mean survival time range = 9.8-21.7 hr
There is significant genetic variation in oxygen tolerance and toxicity response among inbred mouse strains, providing a useful model for studying mechanisms of oxygen toxicity.
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Genetic variation modulates oxygen toxicity in mice; leaves open whether host genetics influence human hyperbaric oxygen tolerance.
Hill et al. (1968) studied Oxygen toxicity. 100% oxygen vs. Between-strain comparison was evaluated on Survival time and form of toxic response (mean survival time range = 9.8-21.7 hr). Exposure to 100% oxygen at 3 ATA resulted in significantly different survival times (range 9.8-21.7 hours) and toxic responses among 18 inbred mouse strains.
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