Intravenous insulin infusion successfully reduced serum triglyceride levels to < 500 mg/dl within 3 days on average in patients with hypertriglyceridemia-induced acute pancreatitis.
Observational (n=12)
No
Does intravenous insulin infusion reduce triglyceride levels and improve clinical outcomes in patients with hypertriglyceridemia-induced acute pancreatitis?
Intravenous insulin infusion safely and effectively reduces triglyceride levels and improves clinical outcomes in patients with hypertriglyceridemia-induced acute pancreatitis.
INTRODUCTION: Hypertriglyceridaemia (HT)-induced pancreatitis rarely occurs unless triglyceride levels exceed 1000 mg/dl. Hypertriglyceridaemia over 1,000 mg/dl can provoke acute pancreatitis (AP) and its persistence can worsen the clinical outcome. In contrast, a rapid decrease in triglyceride level is beneficial. Insulin-stimulated lipoprotein lipase is known to decrease serum triglyceride levels. However, their efficacy in HT-induced AP is not well documented. AIM: To present 12 cases of AP successfully treated by insulin administration. MATERIAL AND METHODS: Three hundred and forty-three cases of AP were diagnosed at our clinic between 2005 and 2012. Twelve (3.5%) of these cases were HT-induced AP. Twelve patients who suffered HT-induced AP are reported. Initial blood triglyceride levels were above 1000 mg/dl. Besides the usual treatment of AP, insulin was administered intravenously in continuous infusion. The patients' medical records were retrospectively evaluated in this study. RESULTS: Serum triglyceride levels decreased to < 500 mg/dl within 2-3 days. No complications of treatment were seen and good clinical outcome was observed. CONCLUSIONS: Our results are compatible with the literature. Insulin may be used safely and effectively in HT-induced AP therapy. Administration of insulin is efficient when used to reduce triglyceride levels in patients with HT-induced AP.
Coşkun et al. (Thu,) conducted a observational in Hypertriglyceridemia-induced acute pancreatitis (n=12). Intravenous insulin infusion was evaluated on Decrease in serum triglyceride levels to < 500 mg/dl. Intravenous insulin infusion successfully reduced serum triglyceride levels to < 500 mg/dl within 3 days on average in patients with hypertriglyceridemia-induced acute pancreatitis.