Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na V 1.8 Inhibitors

Clemens Dialer; Sebastian Krüger; Markus Wagener; Marcel Mülbaier; Sebastian Peil; Mauro Marigo; Silke Hagendorf; Lishuang Cao; César Ramírez Molina; Paul Morgan; Clint Young; Lyn Rosenbrier Ribeiro; Inna Slynko; Stefanie Ritter; Monica Guberman; Manuela Hass; Sascha Klosky; Uta la Tendresse; Carsten Gussmann; Sven Kuhnert; Stefanie Peters; Sara Reichardt-Ockenfeld; Hannah Depmeier; Florian Jakob

doi:10.1021/acsmedchemlett.6c00130

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Dialer et al. (2026) studied this question.

synapsesocial.com/papers/6a6d0a91f44fa9f079db8054 https://doi.org/10.1021/acsmedchemlett.6c00130

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Abstract

) in the pain-relevant target tissue (DRG) in rat PK studies. These findings highlight potential of these compounds for further optimization as nonopioid therapeutics.

Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na V 1.8 Inhibitors

Abstract

Discussion

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Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na V 1.8 Inhibitors

Abstract

Discussion

Cite This Study

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