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PhEq_bootstrap is a free software tool that uses the similarity factor (f 2 ) to assess dissolution profile similarity in cases of large data variability. Its theoretical background is founded on bootstrapping, a statistical technique used to simulate the distribution of f 2 values based on the available sample. It allows both justification of profile similarity and prospective simulations for the establishment of the formulation development endpoint. The software is FOSS (free open-source software) and is available online (1).
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Mendyk et al. (2013) studied this question.
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