Key result
Hypertrophic cardiomyopathy mutation carriers had similar quality of life to the general population, though symptoms strongly predicted impaired physical quality of life (beta=5.2, P=0.001).
Why the study?
Are quality of life and psychological distress impaired in hypertrophic cardiomyopathy mutation carriers compared to the general population?
Population
228 hypertrophic cardiomyopathy (HCM) mutation carriers
Design
Cross-sectional
Authors
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Highlights need for psychological support in HCM mutation carriers; leaves open whether routine assessment improves outcomes.
Cross-Sectional (n=228)
Are quality of life and psychological distress impaired in hypertrophic cardiomyopathy mutation carriers compared to the general population?
HCM mutation carriers have similar overall quality of life and distress compared to the general population, but illness and risk perceptions significantly impact these outcomes, highlighting the importance of targeted genetic counseling.
Christiaans et al. (2009) conducted a cross-sectional in Hypertrophic cardiomyopathy mutation carriers (n=228). Hypertrophic cardiomyopathy mutation carriership vs. General Dutch population was evaluated on Overall quality of life and psychological distress. Hypertrophic cardiomyopathy mutation carriers had similar quality of life to the general population, though symptoms strongly predicted impaired physical quality of life (beta=5.2, P=0.001).
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