Quinidine treatment in a child with migrating partial seizures of infancy and a KCNT1 mutation was correlated with a marked reduction in seizure frequency and improved psychomotor development.
Case Report (n=1)
Does quinidine reduce seizure frequency and improve psychomotor development in a child with migrating partial seizures of infancy secondary to KCNT1 mutation?
Quinidine, an antiarrhythmic drug that acts as a partial antagonist of KCNT1, may be an effective targeted treatment for migrating partial seizures of infancy caused by KCNT1 mutations.
Migrating partial seizures of infancy is an early onset epileptic encephalopathy syndrome that is typically resistant to treatment. The most common cause is a gain of function mutation in the potassium channel KCNT1. The antiarrhythmic drug quinidine is a partial antagonist of KCNT1 and hence may be a candidate drug for treatment of this condition. We report the case of a child with migrating partial seizures of infancy secondary to an activating mutation in KCNT1 treated with quinidine. Treatment with quinidine was correlated with a marked reduction in seizure frequency and improved psychomotor development.
Bearden et al. (Thu,) conducted a case report in Migrating partial seizures of infancy (n=1). Quinidine was evaluated on Seizure frequency and psychomotor development. Quinidine treatment in a child with migrating partial seizures of infancy and a KCNT1 mutation was correlated with a marked reduction in seizure frequency and improved psychomotor development.