Why the study?
Does quinidine reduce seizure frequency and improve psychomotor development in a child with migrating partial seizures of infancy secondary to KCNT1 mutation?
Population
A child with migrating partial seizures of infancy secondary to an activating mutation in KCNT1 (n=1)
Design
Case_report
Key result
Quinidine treatment in a child with migrating partial seizures of infancy and a KCNT1 mutation was correlated with a marked reduction in seizure frequency and improved psychomotor development.
Authors
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Quinidine may merit cautious trial in refractory KCNT1 epilepsy; Level 5 case leaves open need for controlled efficacy data.
Case Report (n=1)
Does quinidine reduce seizure frequency and improve psychomotor development in a child with migrating partial seizures of infancy secondary to KCNT1 mutation?
Quinidine, an antiarrhythmic drug that acts as a partial antagonist of KCNT1, may be an effective targeted treatment for migrating partial seizures of infancy caused by KCNT1 mutations.
Bearden et al. (2014) conducted a case report in Migrating partial seizures of infancy (n=1). Quinidine was evaluated on Seizure frequency and psychomotor development. Quinidine treatment in a child with migrating partial seizures of infancy and a KCNT1 mutation was correlated with a marked reduction in seizure frequency and improved psychomotor development.