Key result
S-Ethylisothiourea and bisisothioureas are potent and selective competitive inhibitors of human nitric oxide synthase isozymes, with some analogs showing up to 190-fold selectivity for iNOS over eNOS.
Population
Human and mouse nitric oxide synthase (NOS) isozymes (inducible, endothelial, and neuronal)
Design
Preclinical
Authors
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S-Ethylisothiourea offers a potent in vitro NOS probe; leaves open any cardiovascular therapeutic role pending in vivo validation.
Non-amino acid isothioureas, particularly bisisothioureas, can provide potent and highly selective inhibition of human inducible nitric oxide synthase.
Garvey et al. (1994) studied this question. S-Ethylisothiourea and other non-amino acid isothioureas was evaluated on Inhibition of human nitric oxide synthase (NOS) isozymes (Ki values). S-Ethylisothiourea and bisisothioureas are potent and selective competitive inhibitors of human nitric oxide synthase isozymes, with some analogs showing up to 190-fold selectivity for iNOS over eNOS.
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