Key result
Epidural analgesia compared to intravenous analgesia did not significantly influence the risk of 30-day anastomotic leakage requiring reoperation after open colorectal surgery (HR 0.94; 95% CI 0.53-1.67; P=0.8338).
Why the study?
Does epidural analgesia influence the incidence of anastomotic leakage requiring reoperation in patients undergoing open colorectal surgery for cancer compared to intravenous analgesia?
Cohort (n=1,474)
Does epidural analgesia influence the incidence of anastomotic leakage requiring reoperation in patients undergoing open colorectal surgery for cancer compared to intravenous analgesia?
Hazard Ratio: 0.94 (95% CI 0.53–1.67)
p-value: p=0.8338
Epidural analgesia does not increase the risk of anastomotic leakage requiring reoperation after open colorectal surgery for cancer compared to intravenous analgesia.
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Supports epidural safety in open colorectal resections; leaves open randomized confirmation of leakage neutrality.
Piccioni et al. (2015) conducted a cohort in Open colorectal surgery for cancer (n=1,474). Epidural analgesia vs. Intravenous analgesia was evaluated on Anastomotic leakage requiring reoperation within 30 days after elective operation (HR 0.94, 95% CI 0.53-1.67, p=0.8338). Epidural analgesia compared to intravenous analgesia did not significantly influence the risk of 30-day anastomotic leakage requiring reoperation after open colorectal surgery (HR 0.94; 95% CI 0.53-1.67; P=0.8338).
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