Answers are grounded in this paper and cite their sources.
Demonstrates a novel synthesis method for β3-acylamino amides using multiple reactants, suggesting a valuable way to access complex molecules.
An atom-economical strategy for the synthesis of alkylated β3-acylamino amides via Lewis acid catalyzed one-pot multicomponent reaction of ynamides, carboxylic acids, and aromatic amines with aliphatic aldehydes is described. In addition to the synthetic utility and scalability, the method exhibits excellent substrate scope and functional-group tolerance. The products can easily be transformed into valuable building blocks, such as peptide chains.
No takes yet. Share an insight, caveat, or question.
Zhuang et al. (2023) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: