Direct Monitoring of the Asymmetric Induction of Solid‐Phase Catalysis Using Circular Dichroism: Diamine–CuI‐Catalyzed Asymmetric Henry Reaction

The direct approach: A new high-throughput screening system for analyzing the asymmetric induction in catalytic enantioselective synthesis couples solid-phase reactions with a circular dichroism detection system (see picture). Thus, direct monitoring of asymmetric induction without the need for purification or chromatographic analysis is obtained.