Key result
High resting heart rate within the accepted normal range is independently associated with increased risk of all-cause and cardiovascular mortality.
This review highlights that elevated resting heart rate within the normal range is an underappreciated risk factor for adverse cardiovascular outcomes, and discusses management options for inappropriate sinus tachycardia.
High resting HR in normal range was associated with higher mortality; extends prior observations but leaves causal effects open for trials.
Sinus tachycardia is commonly encountered in clinical practice and when persistent, can result in significant symptoms and impaired quality of life, warranting further evaluation. On the other hand, a growing body of epidemiological and clinical evidence has shown that high resting heart rate (HR) within the accepted normal range is independently associated with increased risk of all-cause and cardiovascular mortality. However, higher HR as a risk factor for adverse cardiovascular outcomes is frequently underappreciated. In this review, we focus on two challenging problems that span the spectrum of abnormally fast sinus HR. The first section reviews inappropriate sinus tachycardia, a complex disorder characterized by rapid sinus HR without a clear underlying cause, with particular emphasis on current management options. The latter section discusses the prognostic significance of elevated resting HR and reviews clinical evidence aimed at modifying this simple, yet highly important risk factor.
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Hottigoudar et al. (2013) conducted a review in Inappropriate sinus tachycardia and elevated resting heart rate. Elevated resting heart rate was evaluated. High resting heart rate within the accepted normal range is independently associated with increased risk of all-cause and cardiovascular mortality.
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