Stoichiometric Leverage: Rapid ¹⁸F‐Aryltrifluoroborate Radiosynthesis at High Specific Activity for Click Conjugation

Raising the 18F3-BAr: Specific activities of most 18F-labeled radiotracers fall below 2 Ci μmol−1, yet 18F-aryltrifluoroborate synthesis affords specific activities as high as 15 Ci μmol−1. This has been confirmed by using click chemistry to link an [18F]-ArBF3− to rhodamine and thereby demonstrating a rapid and generalizable one-pot method for preparing a fluorescent tracer with about 10-fold higher specific activity than usual.