Key result
Sequential pathological changes in respiratory distress syndrome progress from initial thromboemboli to congestion, hemorrhage, hyaline membranes, and eventually pulmonary fibrosis in survivors.
Observational (n=200)
The study outlines the sequential pathological progression of respiratory distress syndrome, explaining its clinical manifestations.
Sequential pathology in respiratory distress syndrome is hypothesis-generating; prospective studies needed before clinical application.
The sequential pathological changes of the respiratory distress syndrome have been assessed in 200 lung biopsies and autopsy specimens over the past ten years. The initial microscopic changes consisted of thromboemboli in pulmonary arterioles. These were followed by congestion and interstitial edema and hemorrhage over the next 24 hours. Intra-alveolar hemorrhage next became evident and reached a peak at 72 hours. Following this, hyaline membranes became the predominant lesion. Bronchopneumonia may be superimposed on these changes at any point from this time on. If the patient survived for a matter of weeks or months prior to death, pulmonary fibrosis was the terminal lesion. The variable combination of these pathological changes explains the clinical manifestations of the respiratory distress syndrome.
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F. William Blaisdell (1974) conducted an observational in Respiratory distress syndrome (n=200). Pathological assessment was evaluated on Sequential pathological changes. Sequential pathological changes in respiratory distress syndrome progress from initial thromboemboli to congestion, hemorrhage, hyaline membranes, and eventually pulmonary fibrosis in survivors.
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