Inhibition of Aβ aggregation has shown promising against Alzheimer's disease in clinical trials. X. Qu and co-workers report a novel strategy on page 1722 which can dissociate amyloid aggregation using local heat generated by a clinically used amyloid-staining, dye-modified graphene oxide (GO) under NIR laser irradiation. With its high NIR absorbance, good biocompatibility, and its ability to cross the blood-brain barrier, the newly synthesized GO can efficiently dissociate Aβ fibrils, protect cells against Aβ-related toxicity, and be monitored in real time.
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Li et al. (2012) studied this question.
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