Key result
Intra-articular expression of human IL-1 beta via gene transfer in rabbit knee joints induced severe arthritis with intense inflammation and cartilage erosion analogous to human rheumatoid arthritis.
Authors
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IL-1β overexpression induces aggressive arthritis in rabbits; leaves open its causal role and therapeutic targeting in human RA.
Ghivizzani et al. (1997) studied Rheumatoid arthritis model. Ex vivo gene transfer of human IL-1 beta was evaluated on Induction of arthritis pathologies. Intra-articular expression of human IL-1 beta via gene transfer in rabbit knee joints induced severe arthritis with intense inflammation and cartilage erosion analogous to human rheumatoid arthritis.
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