Key result
Understanding the nucleo-cytoplasmic transport system utilized by viruses may advance the development of antiviral agents targeting host cell nuclear proteins to control viral replication.
Why the study?
Understanding how viruses exploit host cell nuclear proteins and the nucleo-cytoplasmic transport system can advance therapeutic strategies to produce effective antiviral agents.
Understanding viral exploitation of nucleo-cytoplasmic transport systems may guide the development of novel antiviral therapeutics.
Answers are grounded in this paper and cite their sources.
May inform antiviral targeting of nuclear transport; leaves open clinical validation of host-directed therapies.
Viruses are obligate intracellular parasites that exploit host cell machineries for replication. In this review, we focus on the current understanding of host cell nuclear proteins whose translocation from the nucleus to cytoplasm is induced and utilized by viruses to support viral replication and infection. Utilization of nuclear proteins for viral replication and infection involves disruption of nuclear import, enhancement of nuclear export, removal of nuclear localization signal (NLS) from nuclear proteins and alteration of nuclear pore complexes (NPCs) to cooperatively support viral replication. Understanding of nucleo-cytoplasmic transport system, and associated mechanisms, utilized by viruses will advance therapeutic development of strategies to produce optimal antiviral agents effective in control of viral diseases.
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Meng et al. (2019) conducted a review in Viral replication and infection. Targeting nuclear proteins was evaluated. Understanding the nucleo-cytoplasmic transport system utilized by viruses may advance the development of antiviral agents targeting host cell nuclear proteins to control viral replication.
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