Key result
In 9 hypertensive subjects with angina pectoris, labetalol diminished the incidence of spontaneous and exercise-induced chest pain, lowered blood pressure, and increased exercise tolerance.
Why the study?
Does labetalol reduce chest pain and lower blood pressure in hypertensive patients with angina pectoris?
Does labetalol reduce chest pain and lower blood pressure in hypertensive patients with angina pectoris?
Labetalol is effective in reducing angina episodes and lowering blood pressure in hypertensive patients with angina.
Hypothesis-generating for combined alpha-beta blockade in hypertensive angina; larger RCTs needed before practice change.
1 In nine hypertensive subjects with angina pectoris, labetalol diminished the incidence of chest pain occurring spontaneously or induced by exercise. 2 Labetalol lowered BP in all subjects. 3 Exercise tolerance at maximum levels was increased by labetalol. 4 Improved cardiac function by labetalol may be related to decreased afterload on the left ventricle, and diminished oxygen utilization by the myocardium.
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Besterman et al. (1979) studied Hypertension with angina pectoris (n=9). Labetalol was evaluated on Incidence of chest pain occurring spontaneously or induced by exercise. In 9 hypertensive subjects with angina pectoris, labetalol diminished the incidence of spontaneous and exercise-induced chest pain, lowered blood pressure, and increased exercise tolerance.
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