Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system

Q: What does this research mean for the field?

Human herpesviruses hijack the host SUMOylation machinery to promote viral replication, immune evasion, and the establishment of latency. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sairam Dasika; Janna M. Bigalke

doi:10.1016/j.coviro.2026.101570

July 30, 2026Current Opinion in VirologyOpen Access

Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system

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Key Points

This review investigates the relationship between human herpesviruses and the SUMOylation process in the immune system.
Review of existing literature on the interaction between human herpesviruses and SUMO proteins.
Analysis of how viral proteins influence the SUMO pathway and immune response mechanisms.
Human herpesviruses are shown to hijack SUMOylation for enhanced viral replication and immune evasion.
Discussion of key viral proteins that alter SUMO pathways, contributing to viral latency and persistence.

Implication

Review explores how human herpesviruses manipulate the SUMO pathway, impacting immune responses and viral dynamics.

Abstract

SUMOylation regulates critical cellular processes, including DNA repair, transcription, and immune responses. Human herpesviruses (HHVs) have evolved mechanisms to hijack the SUMO pathway, promoting viral replication, immune evasion, and establishment of latency. This review explores how HHVs manipulate the host SUMOylation machinery, detailing key viral proteins and their effects, as well as antiviral defense mechanisms.

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Cite This Study

Dasika et al. (2026) studied this question.

synapsesocial.com/papers/6a6d97eae258b358b3c6aba2 https://doi.org/10.1016/j.coviro.2026.101570

View Full Paper

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Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system

Key Points

Implication

Abstract

Discussion

Cite This Study

Molecular grappling: the complex interplay involving human herpesviruses, small ubiquitin-like modifier (SUMO), and the host immune system

Key Points

Implication

Abstract

Discussion

Cite This Study

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