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August 1, 2026Neurology

Association of Sugar Restriction in Utero Through Age 2 Years on Dementia Risk Later in Life

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Authors

JZJiazhen ZhengGLGregory Y.H. LipZZZhuoni Zhang

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Overview

Randomized trial finds lower dementia risk in individuals exposed to sugar rationing during early life, suggesting preventive strategies.

Key Points

  • This research investigates the link between sugar restriction in early life and the risk of developing dementia later in life.
  • Analyzed data from 64,737 UK Biobank participants born around the end of UK sugar rationing.
  • Classified exposure to sugar rationing during various life windows: in utero only, first year, or 1-2 years after birth.
  • Used Cox and Gompertz models to estimate hazards ratios and Fine-Gray models for competing risks.
  • Sugar rationing in utero plus the first year of life reduced all-cause dementia risk (HR, 0.79; 95% CI 0.66-0.94).
  • Similar outcomes were observed for AD (HR, 0.77; 95% CI 0.59-1.00) with a delayed onset of 2.87 years.
  • Higher gray matter volume and better cognitive performance were noted in those exposed to sugar rationing.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/6a6d97eae258b358b3c6abeehttps://doi.org/10.1212/wnl.0000000000218313
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