Randomized trial examines distinct roles of childhood trauma and genetic risk on cognition in schizophrenia patients, indicating different implications.
Key Points
This research investigates how childhood trauma and polygenic risk influence cognitive function and brain dynamics in schizophrenia.
Included 164 schizophrenia patients and 114 healthy controls, comparing a matched subsample of 117 patients on polygenic risk scores and cognitive assessments.
Utilized resting-state fMRI to analyze brain connectivity in patients, stratifying them into high-SczPRS and low-SczPRS subgroups.
Patients with childhood trauma had significantly lower polygenic risk scores than those without.
Higher childhood trauma scores correlated with lower cognitive performance (r = -0.282, p < 0.001) without affecting brain connectivity.
Patients with the highest polygenic risk showed decreased dynamic connectivity between the cinguloopercular network and subcortical networks (F = 7.949, p = 0.007).