In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs

Chizuka Sakai; Eriko Higashi; Shunsuke Iwano; Yohei Miyamoto; Hiroshi Yamazaki; Masashi Uchida

doi:10.1080/00498254.2026.2711041

July 29, 2026Xenobiotica

In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs

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Key Points

The aim is to compare the intestinal and hepatic oxidative metabolism of cytochrome P450 3A substrates across different species.
Conducted oxidative metabolism analysis using midazolam, nifedipine, and quinidine in minipigs.
Compared the findings with metabolism data from humans, monkeys, and dogs.
Utilized both in vitro and in vivo approaches for comprehensive assessment.
Minipigs displayed metabolic pathways that closely resemble those of humans for the substrates tested.
Overall metabolism rates of midazolam, nifedipine, and quinidine varied among species, indicating species-specific differences.
Significant findings suggest that minipigs can serve as a reliable model for studying cytochrome P450 metabolism.

Implication

Compares oxidative metabolism of substrates in minipigs to humans, monkeys, and dogs, highlighting similarities and differences.

Abstract

This study evaluated intestinal and hepatic first-pass metabolism of CYP3A substrates (midazolam, nifedipine, and quinidine) in minipigs and compared results with

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Sakai et al. (2026) studied this question.

synapsesocial.com/papers/6a6d97eae258b358b3c6ace5 https://doi.org/10.1080/00498254.2026.2711041

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In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs

Key Points

Implication

Abstract

Discussion

Cite This Study

In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs

Key Points

Implication

Abstract

Discussion

Cite This Study

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