Randomized trial investigates paracetamol effects on Drosophila, highlighting the influence of life stage and genetics.
Key Points
This research aims to explore how temperature, life stage, and genetic background affect the toxicity of paracetamol in Drosophila melanogaster across generations.
Conducted a generational experiment using five Drosophila melanogaster lines from DGRP;
Assessed acute survival and phenotypic responses to paracetamol at 19 °C and 25 °C;
Measured starvation tolerance and spontaneous activity to evaluate direct and transgenerational effects.
Adult exposure to paracetamol decreased activity and increased starvation resistance;
Juvenile exposure led to variable and sex-dependent responses;
One genotype exhibited significantly higher lethality at elevated paracetamol doses.